The Saints look to bounce back from FA Cup disappointment against a Burnley side unbeaten in three.
Southampton have lost two of their last three league games against Wolves and Liverpool and hope to rediscover some form in this weekend’s clash on the south coast.
Meanwhile Burnley could have easily made it a maximum nine points from nine in an impressive performance against Arsenal and will be looking to carry that momentum forward.
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Despite a minor blip recently, Ralph Hassenhuttl’s side have turned their fortunes around in the past few months.
They looked in deep trouble in the early stages of November but have picked up seven wins from their last 12 to move clear of the bottom three heading into the final straight but will look to extend that seven point gap between them and the relegation zone.
Their revival has been built largely around impressive away form and the goals of former Burnley striker Danny Ings, whose 14 league goals are his best return since scoring 21 times for the Clarets in their promotion-winning season under Dyche in 2013/14.
However, the Saints have not overcome Burnley in any competition since October 2016, and suffered a 3-0 defeat when they travelled to Turf Moor in the Premier League on the opening weekend of the 2019-20 campaign.
The Clarets have also picked up some decent results in the last few weeks, beating Leicester and Manchester United while drawing with Arsenal.
Since losing 3-0 at Chelsea on January 11, they have collected seven points from their three matches like Southampton are moving away from the drop zone.
It is difficult to say that Burnley are safe from the threat of relegation, but Sean Dyche's team have shown enough over the last few weeks to suggest that they will be fine when it comes to staying in the division once again.
Burnley are only above Southampton on goal difference and the loser of this one might be looking over their shoulder if results elsewhere favour the other strugglers.
James Ward-Prowse is hoping to be able to extend his ever-present Premier League record after recovering from a gashed knee sustained in the Saints’ FA Cup replay defeat to Tottenham.
The long-serving midfielder has played the last couple of games at right-back but could return to his normal position with Yan Valery and loan signing Kyle Walker-Peters both available to fill that slot.
Danny Ings and Shane Long should continue as the front two in a 4-4-2 formation, while Moussa Djenepo will be hoping to get the nod over Adam Armstrong in a midfield position.
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The Clarets will be without Ashley Barnes and Johann Berg Gudmundsson – the goalscorers in Burnley’s 3-0 opening day win over Southampton – as they recover from injury.
Matt Lowton might be back in contention following a knock to the knee against Arsenal, while fellow full-back Charlie Taylor (hamstring) will have a late check.
Josh Brownhill could also be involved for the first time since joining from Bristol City during the January window.
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